Past Issue

Drug discovery, a pivotal aspect of pharmaceutical research, involves the identification and development of new therapeutic compounds. However, the process is hampered by challenges such as the labour- intensive nature of screening vast chemical libraries and the need to predict potential toxicity accurately. Common issues include limited labelled toxicity data, the complexity of molecular structures, and the time-consuming nature of experimental validation.

Chronic kidney disease (CKD) patients on hemodialysis often struggle with hyperphosphatemia, a condition that significantly increases cardiovascular disease risk and mortality. Phosphate binders, taken orally with dietary phosphate restrictions, are key in managing elevated serum phosphate levels. Traditional binders include calcium-based and aluminum-based options, while newer alternatives are non-calcium-based binders such as sevelamer, lanthanum, and iron-based agents like ferric citrate.

Gully erosion presents a significant threat to the environment, putting agriculture, wildlife habitats, human safety, infrastructure, and soil health at risk. Mapping areas vulnerable to gully erosion accurately demands selecting the right machine learning model, given the varied environmental factors influencing gully formation.

In the present work is to established simple, accurate, rapid and validated (as per ICH) RP-HPLC method developed for the quantification of Triamcinolone acetonide tablet and injection. In RP-HPLC method the column used was Phenomenex Luna C18, Column (250 mm x 4.6 mm id; 5 µm particle size) and the mobile phase was composed of Acetonitrile: 0.05M Phosphate buffer pH adjusted to 6.8 using NaOH with 0.1% of Triethylamine (55:45 v/v) with flow rate 1ml/min. Eluents were monitored by UV detector at 238 nm.

Entrepreneurship is the act of creating, directing and managing a business or economic activity with the objective of profitability. This often involves taking risks and investing time, energy and resources to develop an idea or project. Entrepreneurs are innovative, creative and motivated people irrespective of caste, religion or gender, who seek to add value to society and realize their professional aspiration. Entrepreneurs often require financial resources to start or grow their businesses. This may involve securing funding from investors, banks, or other sources.

The basic goal of Ayurveda is to keep a healthy person well and shield them from illness.The concept of Panchamahabhuta (five elements) is one of the basic fundamental principle of ayurveda science. It acknowledges that the universe is composed of five fundamental components, i.e Aakaash, Vayu, Agni, Prithvi, Jala ¹. Dosha, Dhatu, and Mala are the primary causative factors responsible for maintaining health and treating diseases, and they too are considered Panchabhautika.

Gogu Shyamala is a well-known Dalit writer and social activist from Andhra Pradesh, and her anthology of short stories entitled Father may be an Elephant and Mother only a Small Basket. Shyamala explores themes of resilience, identity, and social injustice. Each story is a poignant reflection of the daily struggles, cultural richness, and indomitable spirit of these women, highlighting their strength in the face of systemic oppression.

The ever-increasing demand of plastics in the world and their consequent disastrous effects on environment, a suitable environmental-friendly substitute like bioplastics/biodegradable plastics is the need time. Biobased plastics or bioplastics are made from renewable resources, such as corn, potatoes, soy, sugarcane, yam, wheat, and vegetable oil. With the price of oil rising and scarce resources of petroleum, tremendous efforts are being put by researchers to explore a proper and proven alternative to petroleum-based plastics (bio-waste, starch, cellulose, etc).

Del Nido cardioplegia is a favored choice in pediatric cardiac surgery, known for its unique composition with lidocaine to counteract potassium-induced depolarization, minimizing interruptions and enhancing surgical efficiency. Recent research extends its application to adult cardiac surgery, affirming its safety, efficacy, and cost-effectiveness. Limited availability of the standard base solution, Plasmalyte-A, in some regions hinders its use. An alternative approach with lactated Ringer's solution has been explored.

The paper aims to explore the concept of authenticity depicted by the characters Werner Pfennig, a German boy and Marie-Laure LeBlanc, a blind French girl in the novel All the Light We Cannot See written by Anthony Doerr. The novel is a poignant tale of hope, resilience and the human spirit during World War II. The plot follows two young protagonists, Marie-Laure, a blind French girl, and Werner, a German boy, whose paths intersect amid war. The novel explores existentialist themes through the characters’ experiences and struggles.