Past Issue

Hirayama's disease also referred to as monomelic amyotrophy or Sobue disease or juvenile non-progressive amyotrophy, predominantly impacts young males, especially in regions such as India and Japan. It presents as a specific type of focal, lower motor neuron disorder, with its precise cause often elusive.

Cellular angiofibroma, also referred to as angiomyofibroblastoma-like tumor, is a rare type of extratesticular mesenchymal tumor found in the scrotum and perineum. Initially identified predominantly in women's vulva, perineum, and pelvic region, it represents a distinct entity within this spectrum of tumors. Angiofibroma in male population is very rare. We hereby present the case of a 48 year old male patient with gradually progressive, painless swelling in the right scrotum, where USG and MR revealed paratesticular mass.

An adverse drug reaction (ADR) is a response that is noticeably unpleasant or damaging as a result of using a medication, and the Global Trigger Tool is used to efficiently identify these types of events. The Global Trigger Tool was used in this study to measure the prevalence of ADRs and evaluate the effectiveness of trigger mechanisms for their identification. Over five months, 300 randomly selected inpatient files were included in a retrospective observational study. Following these files went through to trigger identification, 116 (38.67%) of them included triggers.

Drug discovery, a pivotal aspect of pharmaceutical research, involves the identification and development of new therapeutic compounds. However, the process is hampered by challenges such as the labour- intensive nature of screening vast chemical libraries and the need to predict potential toxicity accurately. Common issues include limited labelled toxicity data, the complexity of molecular structures, and the time-consuming nature of experimental validation.

Chronic kidney disease (CKD) patients on hemodialysis often struggle with hyperphosphatemia, a condition that significantly increases cardiovascular disease risk and mortality. Phosphate binders, taken orally with dietary phosphate restrictions, are key in managing elevated serum phosphate levels. Traditional binders include calcium-based and aluminum-based options, while newer alternatives are non-calcium-based binders such as sevelamer, lanthanum, and iron-based agents like ferric citrate.

Gully erosion presents a significant threat to the environment, putting agriculture, wildlife habitats, human safety, infrastructure, and soil health at risk. Mapping areas vulnerable to gully erosion accurately demands selecting the right machine learning model, given the varied environmental factors influencing gully formation.

In the present work is to established simple, accurate, rapid and validated (as per ICH) RP-HPLC method developed for the quantification of Triamcinolone acetonide tablet and injection. In RP-HPLC method the column used was Phenomenex Luna C18, Column (250 mm x 4.6 mm id; 5 µm particle size) and the mobile phase was composed of Acetonitrile: 0.05M Phosphate buffer pH adjusted to 6.8 using NaOH with 0.1% of Triethylamine (55:45 v/v) with flow rate 1ml/min. Eluents were monitored by UV detector at 238 nm.

Entrepreneurship is the act of creating, directing and managing a business or economic activity with the objective of profitability. This often involves taking risks and investing time, energy and resources to develop an idea or project. Entrepreneurs are innovative, creative and motivated people irrespective of caste, religion or gender, who seek to add value to society and realize their professional aspiration. Entrepreneurs often require financial resources to start or grow their businesses. This may involve securing funding from investors, banks, or other sources.

The basic goal of Ayurveda is to keep a healthy person well and shield them from illness.The concept of Panchamahabhuta (five elements) is one of the basic fundamental principle of ayurveda science. It acknowledges that the universe is composed of five fundamental components, i.e Aakaash, Vayu, Agni, Prithvi, Jala ¹. Dosha, Dhatu, and Mala are the primary causative factors responsible for maintaining health and treating diseases, and they too are considered Panchabhautika.

Gogu Shyamala is a well-known Dalit writer and social activist from Andhra Pradesh, and her anthology of short stories entitled Father may be an Elephant and Mother only a Small Basket. Shyamala explores themes of resilience, identity, and social injustice. Each story is a poignant reflection of the daily struggles, cultural richness, and indomitable spirit of these women, highlighting their strength in the face of systemic oppression.