The herbal plants are widely used as therapeutic agents. In this present study we evaluated the efficiency of Cissus quadrangularis, Michelia champaca and Cassia auriculata against hyperuricemia also called metabolic arthritis) is a disease due to a congenital disorder of uric acid metabolism. These three plant extract was tested with potassium oxonate and allopurinol to check activity against the gout disease. Then finally it was confirmed that given plant extract with those two chemicals reduced uric acid level in the blood and showed significant changes biochemical assays such as Creatinine, Urea, Total protein, Albumin, Globulin, and Albumin Globulin Ratio. The tests for rheumatoid arthritis such as RA test, C-Reactive protein test, and Antistreptolysin O test showed negative result after treatment