Background: Streptococcus Mutansis the first bacterial pathogen seen in early childhood caries (ECC). The use of plant-derived compounds have been used increasing by anti-microbial agents. The purpose of this study was todetermine the antibacterial effect of Chamomile extracts on salivary S. Mutansin children. Methods: In this clinical trial, 50 children aged 9-12 years old were randomly assigned to two groups of 25 (one group has 25 males and the other group has 25 females). Each of the groups received extracts of Chamomile. Saliva samples were collected before intervention and transferred to the laboratory for counting of S. Mutans. Data were analysed by Statistical Package for Social Sciences (SPSS) 20.0 software using paired-sample t-test. Results: The results demonstrated that, Chamomile significantly reduced the S. mutans level at 30 minutes after administration compared to baseline, although its count was still lower than the baseline. Conclusions: The extracts of Chamomile significantly decreased salivary S. Mutans count.
