Introduction: Periodontitis is an inflammatory disease of the supporting tissues of teeth caused by specific group of microorganisms resulting in destruction of periodontal ligament, alveolar bone with pocket formation, recession or both. Aim: To evaluate clinical and radiographic outcome of Nanocrystalline hydroxyapatite (NcHA) bone graft in combination with Advanced platelet rich fibrin( A-PRF) and Platelet rich fibrin ( PRF ) in the treatment of bilateral intrabony periodontal defects. Materials and Methods: Twenty intrabony defects in 9 systemically healthy patients aged between 35‑55 years, were randomly assigned into Group A and Group B. The Plaque index (PI), Gingival index (GI), Probing pocket depth (PPD), Clinical attachment level (CAL), and Radiographic bone fill were recorded. In Group A NcHA bone graft with A- PRF was placed and in the Group B NcHA and PRF was placed, Post operative recall was done at 7th day, 1st month, 3rd month, and 6th month. Results: Statistically significance with p values of < 0.0001was observed for all clinical parameters at group A, Group B pre operatively and post operatively with more significance observed in Group A (NcHA and A-PRF). Conclusion: Group A which was treated with NcHA and A-PRF showed better results when compared with NcHA and PRF in Group B.
