This manuscript reveals the preventive potential of vanillic acid on lysosomal damage in isoproterenol induced myocardial infarction in rats. Wistar rats were pretreated with vanillic acid (10mg/kg) daily for a period of 10 days. After the pretreatment period isoproterenol (100mg/kg body weight) was subcutaneously injected to rats at an interval of 24h for two days to induce MI (11th and 12th days). The levels of cardiac markers were increased significantly in the serum of ISO-induced MI rats. The levels of lipid peroxides TBARS was significantly increased in the heart lysosomal fraction of the heart of ISO-induced MI rats. In addition, the activities of lysosomal enzymes in the serum and heart of ISO- induced MI rats were increased significantly. Pretreatment with vanillic acid prevented the changes in the levels of serum cardiac markers, lipid peroxidation product and the activities of lysosomal enzymes in isoproterenol induced MI rats.
