Introduction: Fixed Drug Eruptions are dermatological manifestations of drug reactions which recurs in the same location after repeated exposure of same drug or related medications. They usually appear as round to oval erythematous plaque which evolves to become dusky and violaceous. So this study was conducted to observe the different drug which are responsible for fixed drug eruption. Methods: This was a observational study over a period of 2 years. In that period we have found 50 patients having fixed drug eruptions which were recruited according to selection criteria. After that proper history was taken in which demographic, clinical, time of start of reaction and drug intake information and were collected. Results: In this study, out of 50 patients, recognition of offending drugs were distinguished in 43 patients. Flouroquinolones (39.53%) were the most common agent for causing FDE followed by Nonsteroidal anti-inflammatory agents (18.60%), Amoxicillin (16.27%), Fluconazole (11.62%), Azithromycin (4.65%), Metronidazole(4.65%) and Doxycycline (4.65%). Conclusion: In this study, Flouroquinolones were the most common agent for causing FDE followed by Nonsteroidal anti-inflammatory agents. So with detailed history and Physical examination was made the diagnosis of fixed drug eruption
