review on analytical method for determination of glimepiride in bulk and in different dosage forms

Research Article
Nusratbanu K. Shaikh
Glimepiride, Spectrophotometric Method, HPLC,UV

Glimepiride first third lowers blood sugar by stimulat increased activity of intracellular insulin receptors. Their mechanism of action to ATP conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage ion concentration induces the secretion of insulin. few years only, available data obtained in randomized controlled trials are of better quality compared to those available with classicalis medium-to-long-acting sulfonylurea antidiabetic drug -generation sulfonylurea, or as second-generation. It acts as an insulin ing the release of insulin by pancreatic beta cells and by inducing -sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium -sensitive calcium channels. This increase in intracellular calcium Despite the glucose-lowering agents, especially in elderly people who. It is classified as either the secretagogue. It is Glimepiride binds y have been commercialized since  a have hypoglycemia. But, their remaining uncertainties and controversies that should be resolved by further ongoing large prospective controlled trials and increasing clinical experie a careful effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. There ar for the determination of Glimepiride in Biological samples and pharmaceutical formulations. This article spectrophotometric m drug