Retinol palmitate prevents development of forelimb in mouse embryo

Research Article
Raju Sharma, K.K. Sharma and Navneet Sharma
Molecular Developmental Biology

Vitamin-A is known for its effects on differentiation and morphogenesis during vertebrate development, as it is important for reproduction, Development and growth. Hypo and hyper vitaminosis-A both provoke epithelial pathologies in animals and human beings. So a critical value of vitamin-A is required in vivo for maintenance of normal architecture and functions of much body tissue. The pregnant female mice of one group were treated with a high dose 4IU/day/ 40gm body weight concentration of Retinol Palmitate (RP) by intubation from 10th day gestation to 15th day gestation. Another group was not given RP treatment serves as control group. The treated mice delivered the externally malformed neonates on 19th day of gestation i.e.2 day earlier. Whereas control group delivered normal neonates on 21st day of gestation. The various external malformaties shown by the neonates of treated group like, absence of forelimb, reduced and without digits hind limb, and also absence of eye and ear.