Research Article
DOI:
http://dx.doi.org/10.24327/ijrsr.2017.0807.0850
Subject:
science
KeyWords:
Propanil, Kidney, Liver, Taurine
Abstract:
The present study was designed to investigate the detrimental effects of propanil on liver and kidney of mice and probable alleviating capability of silymarine against such intoxication effects. Methods: In an experimental study 36 albino mice were distributed in six equal groups of six each as follows: Control group, 100mg propanil/kg, 100mg taurine/kg, 200mg taurine/kg, propanil (100 mg/kg) + taurine (100 mg/kg), propanil (100mg/kg) + taurine200mg/kg. Treatment was via oral route and was fed once daily for 90 days. Propanil revealed marked degenerative and necrotic alterations in kidney and liver. Taurine improved propanil induced histopathological alteration.