Introduction: Mucormycosis is an invasive fungal infection caused by saprophytic fungi belonging to the genera Mucor, Rhizopus and Absidia which belong to the order Mucorales and class Zygomycetes. COVID-19 is a life-threatening, infectious disease in which there is dysregulation of immune system occur due to extensive use of steroids in management or associated with diabetes mellitus which suppress immunity, increasing susceptibility to opportunistic fungal infections to colonize. Materials and Methods: A retrospective study of 500 patients with invasive fungal infection who presented to the ENT department and who were either COVID-19 positive or had recovered from COVID-19 infection, were included in the study. Tissue samples from all suspected site were received in sterile container containing normal saline, were used for KOH smear and culture. Result: A total of 500 patients presented. Out of these patients 226(45.2%) cases were found to be positive for fungal elements based on direct microscopy-KOH. Out of these 226 cases 49(21.68%) cases shows morphology resembling to mucormycosis and 177 (78.32%) positive for other fungi. Out of these 49, 17(34.70%) also shows growth for mucormycosis on fungal culture media. Conclusion: COVID-19 associated with invasive mucormycosis is dangerous. Uncontrolled diabetes and impulsive use of steroids are two of the main factors aggravating the illness. If in infected patient, early surgical intervention and intravenous anti-fungal treatment should be started for management, good prognosis and less fulminant disease course can be achieved.
