Background: Dyslipidemia implies elevated LDL-C, triglycerides and decreased levels of HDL-C. In this study, we aimed to compare non-HDL-C with LDL-C and total Cholesterol as a predictor of cardiovascular risk in patients with Dyslipidemia.
Methods: Retrospective analysis of lipid profile in 1000 subjects having serum cholesterol ≥200mg/dl was done. As per the revised National Control Education Plan (NCEP)-Adult Treatment Panel (ATP) III Guidelines, subjects were divided into 5 groups according to their LDL-C levels. Total Cholesterol, HDL-C, and LDL-C were measured with the enzymatic method on Roche Modular P800 whereas non-HDL-C (Total Cholesterol minus HDL-C), LDL-C/HDL-C and TC/HDL-C ratios were calculated.
Results: Highly significant levels of non-HDL were seen in all the 5 groups. non-HDL-C significantly correlated with total Cholesterol (p-value <0.00001), LDL-C (p-value <0.05), TC/HDL-C ratio (p-value <0.00001) and LDL-C/HDL-C ratio (p-value <0.05) in all the groups. Conclusion: Based on the findings of the present study it was observed that the measurement of non HDL, TC/HDL-C ratio, and LDL-C/HDL-C ratio can provide more relevant information to the Cardiovascular risk than LDL-C alone in Dyslipidemia.
