Knockout Mouse Models For Human Diseases

Research Article
Muhammad Nazir, Suruchika Gaur, Abdallah Alsaadi, Mahmoud Yasser and Mohammed Saif
Social science
Knockout mouse, homologous recombination, knockout

Knockout mouse models are the mice used as a model to study human diseases by knowing the function of genes causing disease or study the function of unknown genes It can be done using transgenic mice with introducing a foreign gene or deleting an existing gene in them. Knocking out a gene that is corresponding to disease will cause the disease in mice. Knockout mice resemble the human disease in similar gene which is used to find new drug targets and try different treatments on mice to see the effect. To introduce a knockout gene in mice, either homologous recombination or Cre-lox system must be used. Knockout mice are produced to study and compare different dysfunction genes with human diseases to come up with a treatment for different cases.