Background: Tamoxifen (TAM) is a frontline therapy for treatment of hormone-dependent breast cancer. Despite its efficiency as a chemotherapeutic agent in women, its associated toxicity is well established in several organs and tissues. Methods and Findings: The present study was designed to investigate the protective effect of green tea (Camellia sinensis) extract (GTE) against renal injury induced by TAM citrate in rats. For this purpose, forty adult female rats were divided equally into 4 groups; untreated control, TAM (received 45 mg/kg/day for 7 successive days, intraperitoneal), GTE (given 1.5% w/v in water as the sole drinking fluid for 21 days), and TAM-GTE (received the same doses of both TAM and GTE). Administration of TAM induced renal dysfunction as shown by elevation in urea and creatinine levels in the serum. It also disturbed the oxidant/antioxidant status and induced oxidative stress in renal tissue. This was evidenced by augmentation of lipid peroxidation (measured as malondialdehyde, MDA) as well as depletion in the major antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the kidney. Furthermore, TAM induced histopathological changes in the renal tissue. Supplementation with GTE for 21 days improved the kidney function and restored its oxidant/antioxidant balance. These biochemical findings were supported by the histological examination. Conclusion: In conclusion, GTE could be beneficial in attenuating TAMinduced renal injury and oxidative stress possibly due to its antioxidant properties
