evaluation of the pharmacological properties of schiff base mixed ligand cu (ii), co (ii), ni (ii) and zn (ii) complexes derived from 2-((e)-(4 nitrophenylimino) methyl) phenol

Research Article
Usharani .M., Akila .E And Rajavel* .R
DOI: 
xxx-xxxx-xxx
Subject: 
science
KeyWords: 
Biological screening, Disc diffusion, Inhibition, DNA binding, mononuclear complexes.
Abstract: 

The coordination chemistry of 2-((E)-(4-nitrophenylimino)methyl)phenol (L1) and 1-(4- chloro-phenylazo)-naphthalen-2-ol (L2) has been investigated with the Cu(II), Co(II), Ni(II) and Zn(II) ions. These two ligands offer two coordination modes through phenolic oxygen and azomethine nitrogen. The effective magnetic moment, ESR and electronic spectral data supported the square planar environment of the metal ions. Spectroscopic methods like infrared spectroscopy and 1H NMR were used for structure elucidation of the complexes. The pharmacological properties of the synthesized ligands and their mixed ligand complexes were evaluated against microbial (against the bacteria such as Escherichia coli, Staphylococcus aureus, Klebsilla pneumonia and Bacillus subtilis, and the fungi such as Aspergillus flavu and fungi Fusarium oxysporum) and CT DNA to assess their inhibitions and interactions potential.