In accordance with the general assumption that oral use of herbal products is not harmful, there is not much data available about their potential for toxicity. This makes it difficult to assess the safety of herbal extracts used as food and medicine. In India, Sri Lanka, Thailand, Nepal, and other countries with subtropical climates, Coleus forskohlii, a member of the Lamiaceae family, flourishes as an aromatic plant. Since the plant is administered orally, only limited information is known about its safety. The current study's objective was to evaluate the acute oral toxicity of C. forskohlii root extract (Colegex®) in female albino Wistar rats. The OECD Guideline 423 protocols were used to conduct acute oral toxicity research on C. forskohlii (Colegex®). To ascertain the median lethal dose over a 14-day period, C. forskohlii (Colegex®) was administered orally once daily to the three rats in the treatment group at a dose of 2000 mg/kg bw. Even though the limit dose was kept at 2000 mg/kg bw throughout the 14-day study period, C. forskohlii (Colegex®) did not cause any mortality. Throughout the time frame of the experiment, all of the animals appeared healthy. A single oral dose of 2000 mg/kg bw of C. forskohlii (Colegex®) did not result in any clinical signs or death in rats examined over a 14-day period. More than 2000 mg/kg bw is determined as the median lethal dose for C. forskohlii (Colegex®).
