Elevated Ratio Of Vldl/Hdl In Hypothyroidism May Indicate Future Risk Of Renal Dysfunction

Research Article
Joshi P. N and Rakshasmare P.G
Lipoproteins, renal dysfunction, VLDL, hypothyroidism.

Hypothyroidism is characterized by hypercholesterolemia and hypertriglyceridemia. This deranged levels of lipid and lipoproteins over a long period of time may affect functioning of kidney by various mechanisms. Thus estimating levels of lipids and lipoproteins become an important diagnostic and prognostic tool. Material and methods: The present cross sectional study included 30 clinically diagnosed and biochemically confirmed cases of hypothyroidism compared with 30 age and sex matched controls. Results: It was observed that serum levels of triglycerides, Very low density lipoprotein were increased highly significantly (P < 0.001), while levels of HDL was decreased significantly (P < 0.05) in the experimental group as compared to control. The ratio of VLDL/HDL and TG/HDL were also increased highly significantly (P < 0.001) in the experimental group as compared to control. Conclusion: Thus it can be concluded that elevated ratio of VLDL/HDL and in hypothyroidism may indicate future risk of renal dysfunction.