Background: Diabetes is a long-standing disease characterized by hyper glycemia. This hyper glycemia considered as a primary culprit of diabetic complications and is associated with increased metabolic processes and oxidative stress. The trace elements are important co-factors in these events.
Objectives: In the present study we estimated the serum zinc, magnesium, copper and glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus and healthy controls. A correlation of serum zinc, magnesium and copper with glycosylated hemoglobin (HbA1c) is done in diabetic subjects.
Material and methods: The present study was carried out in the Department of Biochemistry on 360 subjects in the age group of 35-70 years, attended OP in Hind Institute of Medical Sciences. Among them 180 healthy subjects enrolled as control group remaining 180 T2DM patients were served as case group. Fasting venous blood sample was analysed for fasting blood sugar (FBS), serum zinc, serum magnesium, serum copper and glycated hemoglobin (HbA1c). Statistical analysis was done using student‘t’ test .Pearson’s correlation between the study variables was performed to establish the relationship.
Results: The FBS, serum copper and HbA1c levels were significantly elevated in diabetics compared to healthy controls (p<0.001). There was significant decrease in the levels of serum zinc and magnesium levels in diabetics compared to the controls (p<0.001).There is a positive correlation between serum copper with HbA1c, while there a highly significant negative correlation between serum zinc and magnesium with HbA1c in diabetic patients.
Conclusion: Diabetic patients showed a positive correlation between serum copper with HbA1c and a negative correlation between serum zinc and magnesium with HbA1c.
