comparative in vitro activity of mebatic against clinical isolates

Research Article
Manu Chaudhary and Anurag Payasi*
Clinical isolates, fluoroquinolones, Mebatic, ofloxacin, ornidazole.

Study was aimed to explore the in vitro effect of ofloxacin and ornidazole (Mebatic) combination as compared with other drugs on aerobic and anaerobic bacteria. The study was done from March 2014 to March 2015 in the Department of Microbiology, Venus Medicine Research Centre, Baddi, Himachal Pradesh. A total of 1059 clinical samples were collected in a sterile container for aerobic and anaerobic culture. Identification of bacteria was done by microscopy and biochemical reaction. The antibiotic sensitivity testing was performed by cup plate method.

Out of 1059 samples, 605 samples showed the growth of bacteria. Further identification revealed the presence of nine different Gram negative and Gram positive organisms such as included S. aureus, S. pneumoniae, C. trachomatis, N. gonorrhoeae Proteus spp., C. perfringens, Bacteroides spp., Yersinia spp. and Fusobacterium spp. The susceptibility of ofloxacin plus ornidazole (Mebatic) against S. aureus, S. pneumoniae, N. gonorrhoea, C. trachomatis, Proteus spp., Fusobacterium spp, C. perfringens, Bacteroides spp. and Yersinia spp. was > 85% which was high compared to metronidazole, clindamycin alone and, ceftriaxone plus metronidazole, levofloxacin plus metronidazole, moxifloxacin plus metronidazole in combinations. A high resistance to metronidazole (30-100%), clindamycin (25-92.6%), ceftriaxone plus metronidazole (39-88.4%), levofloxacin plus metronidazole (23- 83.0%), ofloxacin plus metronidazole (16-67%) and moxifloxacin/metronidazole (18.9%- 75.2%) was observed.

The study concluded that all the pathogens were found to be highly susceptible to ofloxacin/ornidazole compared to other antibiotics.