Coronary heart disease (CHD) is epidemic in India characterized by premature onset and high mortality. This study shows that premature coronary artery disease in Indians is due to combination of thrombosis and atherosclerotic vascular risk factors. These risk factors are highly prevalent in the community. Prevention and control of premature cardiovascular diseases in India needs urgent control of these factors. Improving lifestyles with tobacco cessation, diet modulation with more fruits and vegetables and lower fat intake, and increased physical activity are critical. Target oriented control of hypertension, lipid levels and glycaemia is required. The study adds that lowering fibrinogen and homocysteine using novel strategies as well as control of all the risk factors from an early age are essential to prevent premature disease.
