Association Analysis Of Ace (Dd) Genotype With Gynoid Chronic Kidney Disease Patients Of Jammu Region (J&K)

Research Article
Meenakshi Bhagat., Jyotdeep K. Raina., Meenakshee Sharma., Ravi Sharma., Rakesh K Panjaliya., Bali S.K and Tripathi N.K
ACE (I/D), CKD, RAS Pathway, Genes, Gynoid, Android, PCR

Background: Angiotensin converting enzyme (ACE) is one the important candidate marker for susceptibility of chronic kidney diseases (CKD), as it is a key regulator of blood pressure and renl physiology. Aim: The present study is aimed to investigate the role of ACE (I/D) polymorphism in Kidney Disease in Jammu Population. Methodology: In the present study a total of 400 individuals (200 cases & 200 controls) were enrolled from Jammu population. The ACE I/D polymorphism was amplified with the flanking primers by polymerase chain reaction (PCR) and was further visualized by 1.5% agarose gel electrophoresis. Results: The overall frequency of variant genotype (DD) was higher in CKD patients in comparison of controls (25% vs 19. 5%). The observed frequency of DD- genotype was lower in male CKD patients than male controls (23.8% vs 26.7%) whereas vice versa was reported for female patients when compared to female controls (26.3% vs 12.1%). The applied genetic models did not reveal any association of ACE I/D polymorphism with risk of CKD. However, [DD vs II (OR=?)] , [DD vs ID + II (OR =?)] and [D vs I (OR =?)] models were significantly associated with riskm of CKD in gynoid group. Conclusion: A significant role of ACE (I/D) polymorphism was reported in gynoid CKD patients of Jammu region (J&K).