Medicinal plants continue to play a central role in the healthcare system of large proportions of the world’s population, particularly true in developing countries like India. We evaluate the tumor inhibitory activity of cadabafruticosa leaf extracts on EAC cells administered mice targeting apoptosis and angiogenesis, which is physiological process involving the growth of new blood vessel from pre-existing one. However, it is also plays a major role in the transition of tumors from a dormant to a malignant stage. The medicinal plant we screened and identified as Cadabafruticosa, which has potent anti-angiogenic and pro-apoptotic activity and expressed direct cytotoxicity to EAC cells by inducing apoptosis as evidenced by decrease in tumor volume, viable cell count and body weight of EAC bearing mice. In treated mice group also found that membrane blebbing, DNA fragmentation, a characteristic features, of cell undergoing apoptosis. Significant anti-angionenic activity was confirmed by its inhibition of angiogenesis in in-vivo peritoneal lining and chorioallantoic membrane assay. Our preliminary results suggest that the Cadabafruticosa leaf extract may be a potent pro-apoptotic and anti-angiogenic agent which may exploit to treat cancer disease as well as in the field of pharmaceutical dug designing.
